Been playing for a bit, some random thoughts so far...
Doesn't feel like the older 3/NV games. Many things have been simplified or removed, like speech, equipment repair, some crafting, speech or intelligence checks
Enemy markers dont show up until youre discovered, sucks for stealth play, hard to pick out enemies with a sniper rifle from a distance
Environment looks nice, but doesnt quite match that steampunk 50's feel of 3 and NV. Weird mix of old and new, almost forced in a way
Radio station kinda sucks. DJ is some nervous dork, got nothing on Three Dog or Mr New Vegas
New HUD is a bit meh
New ghouls, meh as well, just behave like average zombies from an average zombie movie. Old ghouls were way more fun and actually looked more detailed. Now theyre just grey blobs with yellow eyes. Non ferals look like mix of human and Mothership Zeta aliens
Pipboy a bit of a downgrade too