If the stock engine is tuned right 300kw will hang together quite well. The standard internals have ben known to handle this amount of power. Then again plenty of RB25's have let go at less than 200rwkw because of a crap tune or maintence.Also depends on what sort of life the engine has had and how many kms are already on it.
Irrespective of what you do to the internals more power will accelerate wear, a 500HP engine needs rebuilding more than twice as often as a 250HP engine, and it doesn't matter if you have forged pistons and rods etc, the bearings and rings will always wear out. If I ever decided to build a 500HP engine I'd expect to rebuild it (bearings and rings etc) in 60,000kms or less to save me having to buy a whole new set of forgies and things.It's just what you do.
It's quite true that 'you get what you pay for'....
...It just that alot of people don't know they are paying to get F#cked