the safc adds/subtracts a percentage of the current reading of airflow at the rpm points and also taking into account your throttle %. it will still add/trim the tune percentage for that rpm point regardless of the boost pressure.
using you eg.
say at 15psi, 5000rpm, 100%Throttle, you have 300cfm and tune the safc to remove 5% at that point = 285cfm
then at 10psi, 5000rpm, 100%Throttle, you have 200cfm and the tune is unchanged (5%) you get = 190cfm
the ecu then does the rest for what its knows as to how much fuel is needing for 5000rpm, full throttle and 190cfm or 285cfm.
also take into account that you have changed one of the varibles from the original tune so there is no saying that the tune will be exactly right. on the safc2 you can have two maps, you could get one tuned at 15psi and one at 10 psi.