GiJOr33, you reasoning is right, however Sydneykid indicated that the airflow in the GTR / GTR Style manifolds was biased *towards* 6 & 5, rather than the other way round, so they run lean.
He also stated that this (air distribution) was not a problem on the 20/25's, so *if* there was going to be a cooling problem at the back of the engine, it would be cooling related, not mixture related, so changing your mixtures would be working against the goal of optimum tuning.
IF testing with EGT probes (not lambda in this case) or similar indicated that there was a problem with cooling, then you would be better off tapping in a coolant line to the back of the block to better distribute the coolant.
And upgrading the water pump and radiator on any high po engine, esp a turbo one, is never a bad idea. Provided your thermostat works properly, then you can't have too much cooling : )