Yass or Gundagai are generally the best spots to stop over for the night as they are about half way and thats where most people go so its not just some one horse town like some on the hume. Personally I cant just stop after 6 hours I just wanna get where I'm going and just keep driving. I've done the run a couple of times now, was gonna stop in Yass, couldnt be bothered so I just kept driving all the way to Sydney. If you do decide to do it in one go, take plenty of Coca Cola and chocalate bars to keep you perked up. And if you got in car screen put on a movie or something to keep you awake and have an "i'm really f**kin tired" cd full of really loud techno or rock to keep you awake, worked for me. Also do some speeding for me, when I did the last run I had a mattress on the roof of my car for 14 hours straight couldnt drive faster than 80km/h without the bloody thing trying to fly off