I have had experience with a motec M48, on my previous r33. Obviously with the Nistune system there is no setting up, i think its a breeze to use, and also great value for money. I already had the eprom socket in my ECU so i only had to solder 4 wires to the board, plug the daughter board into the socket and away it goes. I sent matt the bin file from my ECU, he installed it onto the board before sending it to me and car started straight up with same settings it has had since i bought the chip off Ceffie.
I just installed a z32, took 2 mins to reprogram for the bigger AFM, also have a set of GTR injecters coming and they are just as easy.
Download the user manual from his site, pretty well explains the uses of it.
Ken