That depends on a lot of things. I wouldn't blanket say it goes out the window.
I'd say if you have a shit tune, and are running 10psi into a stock with either method, and attending track days/drags/industrial park skids(jk) regularly THEN I would say reliability goes out the window.
Simple facts are, if you stick to a low boost level, drive sensibly, and pay close attention to servicing and cooling, then I don't think reliability is affected at all. Facts are that there are many FI cars rolling around with 30, 40, 50 thousand MILES (and even more in some cases) under their belts.
Oh, and I did figure that OP is on P's too. Which makes both suggestions of S/C or upgrade to a 350 useless