Says in your profile you are 27...
Anyhoo - Bourke St Mall has usual clothes-brand shops.
Bridge Rd in Richmond has factory outlets and such - jump on a 75 tram at the corner of Russell and Flinders. Fashion labels - catch an 8 tram from Swanston St to corner Toorak Rd and Chapel St in Sth Yarra (lots of bars/clubs there too).
Cross the river on Swanston to get to Southgate - bars, restaurants and some shops, and walk to Crown Casino for bars, restaurants, shops and gambling.
What weekend are you down? We are having SAU drinks in Sth Yarra next Sunday (25th) - you'd be more than welcome to come along.